THE IMMA PROJECT

Integrating Multiple Meta-Analysis (IMMA) into health care praxis and research is a framework for establishing, disseminating and integrating the ‘second-generation’ meta-analysis toolkit. The objectives of the program are:

  1. to establish and enrich  the emerging MTM toolkit by tackling specific controversial issues and consolidating the methodology
  2. to disseminate MTM and make it more useful and applicable for clinical practice and
  3. to extend the idea of multiple meta-analysis into molecular epidemiology context and suggest sensible approaches to combine evidence from clinical and genetic experiments

Multiple-Treatments Meta-analysis (MTM) has provide a paradigm shift in health care research because it does not address questions of association in the traditional context of a single factor; instead, it considers evidence in the more realistic setting of all relevant and interrelated evidence sources that best inform clinical practice and decision-making. Moreover, multiple meta-analysis has the potential to answer crucial methodological questions regarding biases (such as the impact of novelty and sponsorship bias) which are non-identifiable in a head-to-head meta-analysis and therefore were difficult or impossible to tackle so far. MTM will be proven most useful in understanding pathology, informing policymaking, identifying gaps and methodological deficiencies in the existing evidence and planning future studies.

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